At least 4 fatalities, 11 injuries reported after UPS plane crash in Louisville, Kentucky

Karla Ward and Tessa Duvall, Lexington Herald-Leader on Nov 4, 2025

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LOUISVILLE, Ky. — At least four fatalities and 11 injuries were reported following an early evening plane crash in Louisville on Nov. 4, officials said Tuesday evening.

Some of the injuries were “very significant,” Gov. Andy Beshear said in an update at 7:30 p.m.

Beshear said he expects the number of dead and injured to grow. The governor additionally said the status of the crew is unknown at this time.

A fourth fatality was confirmed as of 9:15 p.m., according to airport public safety officer Jonathan Biven.

At around 5:20 p.m., UPS Flight 2976 with three crew members on board was departing Louisville bound for Honolulu, Hawaii, when “an accident” occurred, according to UPS.

The crash impacted two businesses in the area: Kentucky Petroleum Recycling Plant and Grade A Auto Parts, Beshear said.

“We are seeking more information, but it looks like they were hit pretty directly,” Beshear said of the recycling plant.

Grade A Auto Parts said all but two employees were accounted for.

UofL Health treated 10 patients related to the crash, said David McArthur, director of public relations for UofL Health. UofL Hospital treated two people in the burn center who were in critical condition. Eight others were treated for non-life-threatening injuries at multiple UofL Health locations.

Emergency crews responded to the scene of the crash. The National Transportation Safety Board is leading the investigation.

All flights out of Muhammad Ali International Airport are suspended as of Tuesday evening.

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